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Director, Outcomes Research - Vaccines

Job Description

Our Quantitative Sciences team use big data to analyze the safety and efficacy claims of our potential medical breakthroughs. We review the quality and reliability of clinical studies using deep scientific knowledge, statistical analysis and high-quality data to support decision making in clinical trials. 

Under the guidance of an Executive Director, within the Center for Observational and Real World Evidence (CORE) the incumbent has the following responsibilities:

  • Development of the integrated evidence strategy to support Health Technology Assessment (HTA)/ reimbursement/ National Immunization Technical Advisory Groups (NITAG)evaluations;

  • Development of overall Real World evidence strategies, for one or more in-line and/or developmental drugs and/or vaccines on a worldwide basis and

  • Development and implementation of Outcomes Research (OR) and Real World evidence programs to meet the value evidence needs of payers, advisory committees health systems, and clinicians.

The incumbent can generate these plans based on direct interactions with HTA agencies, HTA/reimbursement experts and our company's country affiliates to obtain in-depth understanding of country specific HTA/reimbursement needs for the product and gain input on research design and implementation of retrospective database studies, assessment of patient reported outcomes, epidemiological studies and economic modeling.

The Director also works closely with Product Development Teams, Franchise Teams, Regional Product Directors, our company's affiliates, Public Affairs, and Medical Education to ensure value evidence programs are consistent with marketing strategies in key countries. Represents CORE on one or more Value and Evidence Sub-teams (VEST) and provide leadership in developing the outcomes research strategies and plans for developmental compounds and obtains cross-divisional senior management approval.

Critically assesses drivers and barriers to reimbursement and market access and identifies value evidence needs to provide strategic input into clinical and market development programs.  Brings strong payer and HTA/reimbursement focus into the Product Development Team(s).

  • Develops the integrated evidence strategy including HTA/OR strategy and generates evidence for HTA/reimbursement purposes.

  • Develops and evaluates health programs leveraging different parts of health care systems that can enhance value and use of our company's products.

  • Implements programs to document the burden and cost of diseases, unmet medical need, patient reported outcomes (PRO) and the value of drug therapy as outlined in the OR planning process and generates data on a worldwide basis to support pricing and reimbursement.

  • Develops value evidence deliverables (e.g., global value dossier, health economic evaluations) and their adaptation to generate country-specific data supporting pricing and reimbursement.

  • Works closely with the VEST team members to develop OR plans for our company's in-line and developmental products based on the regulatory, marketing and reimbursement environments on a worldwide basis, including the local needs of the US Market.

  • Works with our Research Division colleagues, our company's affiliates and consultants to write, coordinate, and validate as required, study designs, protocols, measurement questionnaires, case report forms, data analysis plans, and final reports/publications.

  • Works with our company Investigator Study Program Committee to evaluate outcomes research study protocols for studies in local markets.

  • Supports our company's affiliates to understand local needs, adapt health economic evaluations, customize Outcomes Research documents such as protocols and reimbursement dossier, which includes the development of the worldwide template document including global value dossier and input forms, design of data collection forms for customization to countries, and in collaboration with our company's affiliates, adaptation of the document according to local requirements. 

  • Works closely with other departments to effectively develop/ communicate Outcomes Research findings/value evidence and support data and consistent messages throughout our company and to external customers.

  • Responsible for maintaining awareness of scientific developments within his/her areas of expertise, both in terms of new methodology and new activities to establish communications with key outcomes research opinion leaders.

  • Leverages other groups within CORE to develop and execute OR plans, including Market Partners, Data Sciences and Insights, and Pharmacoepidemiology

  • Builds relationships with health economic and outcomes research experts worldwide.

Other activities :

  • Provide scientific oversight and mentorship to more junior members of the team.

  • Present research plans and results to internal review and governance committees;    to external experts and agencies (e.g. Public Health England) and at scientific conferences.

  • Maintain recognition as an expert in his/her field; publish independent scientific research in major journals, participate in and present at scientific meetings and conferences, and serve as a peer reviewer for scientific journals.

Competencies and skills:

  • In-depth understanding of HTA/reimbursement and market access needs in key global markets

  • 5+ years post PhD or 7+ years post Masters degree of relevant experience in the areas of health economics, outcomes research, market access, HTA or related field.

  • Demonstrated expertise in the design and implementation of epidemiological or health economic studies

  • Demonstrated expertise in the fields of outcomes research, health services research, epidemiology or health economics, and/or health technology assessment.

  • A track record of scientific presentations and publications.

  • Creative problem-solving and excellent communication skills (oral and written)

  • Willing to travel (up to 10% of the time)

  • Fluent spoken and written English

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

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New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

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Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role’s pay range.

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

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Requisition ID:R190669

Director, Outcomes Research - Vaccines

Philadelphia, PA
Full Time

Published on 08/06/2022

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