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Principal Scientist, Transporters and In Vitro Technologies

Job Description

Merck is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.

The Division of Preclinical Development in ADME and Discovery Toxicology at Merck Research Laboratories is seeking a dynamic and collaborative Principal Scientist to join the Transporter & In Vitro Technologies (T&IVT) in West Point, PA.  The T& IVT group is a center of excellence supporting Merck’s discovery and development portfolio by developing and executing assays that predict the impacts of drug transporters and metabolizing enzymes on absorption, distribution, metabolism, and excretion (ADME), drug-drug interactions (DDIs), efficacy, and toxicity of drugs.     

As a subject matter expert, the Principal Scientist within the T&IVT Group will lead collaborative, cross-functional team of scientists to contribute to discovery and development of novel chemical entities.  The primary responsibility of the Principal Scientist is to provide ADME strategy centered around distribution and transporter across a diverse portfolio including neuroscience and infectious disease. The organization provides critical support in early discovery through development to position programs for clinical success.  The Principal Scientist will also take the leadership role to advance our scientific strategy via developing novel tools/technologies to improve translation of in vitro data to predict transporter related drug disposition, DDIs, and interplay with drug metabolizing enzymes. 

Successful candidates should be a subject matter expert in drug transporters and have an in-depth understanding of the impact of drug transporters on the discovery and development of new chemical entities. The successful candidate must be able to work collaboratively in a fast-paced environment, drive scientific strategy and innovation, and have excellent leadership, organization, communication, and collaboration skills.

Position Qualifications:

Education Minimum Requirement:

  • A Ph.D. or equivalent degree in a relevant field (e.g. Pharmaceutical Sciences, Biochemistry, Biology, Molecular and Cell Biology, Pharmacology, Biomedical Engineering) with preferred 5+ years of industry experience

  • A MS or equivalent degree in a relevant field (e.g. Pharmaceutical Sciences, Biochemistry, Biology, Molecular and Cell Biology, Pharmacology, Biomedical Engineering) with 12+ years of industry experience

Required Experience and Skills:

  • A demonstrated scientific leader with extensive experience in drug transporters, with a broad knowledge and understanding of drug discovery and development for small molecules and peptides

  • Representation on discovery and/or development project teams as a subject matter expert designing strategy to address transporter related issues, integrating data into program decision-making, including DDI risk assessment

  • In depth understanding of regulatory requirements and experience providing stage appropriate data sets in drug discovery and development

  • Generation of high quality regulatory documents and ability to address regulatory questions in relevant area

  • Ability to formulate hypotheses and design mechanistic studies to solve problems of high complexity

  • Leadership of departmental task forces/teams for scientific initiatives and capability builds

  • Excellent leadership, organization, communication, and collaboration skills

  • Experience mentoring and scientific supervision of junior staff

  • Strong record of publication in peer-reviewed journals in the ADME discipline

Preferred Experience and Skills:

  • Fundamental understanding of drug metabolizing enzymes and their impact on DDIs.

  • Experience in partnering with CROs to generate quality in vitro transporter and metabolizing enzyme related data

  • Experience working with novel in vitro tools and emerging technologies such as microphysiological systems

  • Good understanding of pharmacokinetics (PK) and knowledge of predictive modeling approaches for translation of in vitro transporters and enzymes data to predict PK and DDI of drugs

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

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Requisition ID:R135086

Principal Scientist, Transporters and In Vitro Technologies

Rahway, NJ 07065
Full Time

Published on 01/15/2022

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