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Senior Scientist, Discovery Biology Retinal Diseases

Job Description

Our company's Research Laboratories in South San Francisco is a brand-new innovation hub designed to foster collaboration between scientists to discover new medicines to improve human health. Retinal Diseases Discovery Biology group is seeking a driven and creative Senior Scientist to join our drug discovery team. This is an exciting opportunity for an independent scientist to drive target identification and validation activities in close collaboration with colleagues in Biology, Chemistry and Biologics teams at our Research Division's South San Francisco and across broader company network. The ideal candidate will be an accomplished scientist with proven track record high impact research in retinal diseases with direct hands-on experience with state of the art in vitro pre-clinical models of dry Age-Related Macular Degeneration (AMD). This position requires high level of motivation and enthusiasm for drug discovery coupled with the ability to plan and execute experiments focused on novel target discovery and validation in a highly collaborative environment.

A successful candidate will be responsible for:

  • Developing innovative drug targets to address high unmet medical need in dry AMD

  • Designing and implementing platforms for target identification and validation utilizing in vitro cell-based assays focused on retinal pigment epithelial (RPE) cell biology

  • Providing necessary support to clinical and translational biomarkers groups

  • Independently managing functional deliverables for discovery program(s)

  • Mentoring and developing junior scientists

  • Establishing and maintaining effective collaborations with internal and external partners, including leading academic laboratories

  • Providing scientific expertise in retinal diseases to help formulate drug discovery strategy

Education Minimum Requirement

  • Ph.D. in Molecular Biology, Immunology, Genetics or related biological discipline and at least 3 years of post-doctoral training

Required Skills and Experience

  • Evidence of scientific productivity based on publications, presentations and patents

  • Hands on experience with in vivo and in vitro models of dry AMD including human iPSC derived RPE cell lines

  • Deep knowledge of molecular pathways driving RPE and photoreceptor degeneration in AMD

  • Ability to solve complex biological problems by undertaking innovative approaches and applying state-of-the-art technologies.

  • Expertise in molecular and cellular biology, cell-based assay, and ex vivo sample processing and analysis

  • Excellent oral presentation and communication skills.

Preferred Skills

  • Experience with target ID and validation in an industry setting

  • Deep understanding of retina/RPE/choroid tissue homeostasis and metabolism

  • Experience with various -omics technologies and their application for target discovery (NGS technologies, proteomics and metabolomics)

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. 

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

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For more information about personal rights under Equal Employment Opportunity, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:




VISA Sponsorship:


Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Work Week


Not Indicated

Valid Driving License:

Hazardous Material(s):

Number of Openings:


Requisition ID:R164600

Senior Scientist, Discovery Biology Retinal Diseases

South San Francisco, CA
Full Time

Published on 06/25/2022

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