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The Division of Preclinical Development in ADME and Discovery Toxicology at Merck Research Laboratories is seeking a dynamic and collaborative Associate Principal Scientist to join the Transporter & In Vitro Technologies (T&IVT) in West Point, PA. The T&IVT group is a center of excellence supporting Merck’s discovery and development portfolio by developing and executing assays that predict the impacts of drug transporters and metabolizing enzymes on absorption, distribution, metabolism, and excretion (ADME), drug-drug interactions (DDIs), efficacy, and toxicity of drugs.
Successful candidates should have an in-depth understanding of drug transporters and their impact on the discovery and development of new chemical entities; the experiences of working independently to design, conduct and interpret complex in vitro studies to solve program related issues. Candidates must have demonstrated leadership as well as excellent written and verbal communication skills in a team environment. Candidates should have the capability to establish a close collaborative relationship with other PPDM functional teams to drive discovery and development programs. Candidates will also be expected to work closely with colleagues across our global network to advance our scientific strategy via developing novel tools/technologies to improve translation of in vitro data to predict transporter related drug disposition, DDIs, and interplay with drug metabolizing enzymes.
Education Minimum Requirement:
A Ph.D. or equivalent degree in a relevant field (e.g. Pharmaceutical Sciences, Biochemistry, Biology, Molecular and Cell Biology, Pharmacology, Biomedical Engineering) with 2+ years of experience
A MS or equivalent degree in a relevant field (e.g. Pharmaceutical Sciences, Biochemistry, Biology, Molecular and Cell Biology, Pharmacology, Biomedical Engineering) with 8+ years of experience
Required Experience and Skills:
Knowledge in drug transporters and their roles in ADME, DDIs, efficacy and toxicity
Design, conduct, and interpretation of complex in vitro studies with ability to solve challenging problems
Working knowledge of ADME science for small molecules and peptides with a fundamental understanding of drug discovery and development
Ability to work independently and effectively with some technical & strategic guidance from scientific supervisor
Critical thinking to drive data-based decisions
Strong leadership, interpersonal, organization, communication, and collaboration skills in a team environment
Ability to thrive with increasing levels of responsibility and mentor/guide junior scientists
Preferred Experience and Skills:
Experience in partnering with CROs to generate quality in vitro transporter and metabolizing enzyme related data
Experience in use of in vitro data and mechanistic modeling to predict transporter and enzyme related PK and DDIs
Experience with novel in vitro tools such as microphysiological systems (alternative in vitro culture systems, organs on a chip)
General knowledge of pharmacokinetics (PK) and drug metabolizing enzymes
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Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.
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